A histone is a protein that provides structural support for a chromosome. Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes. Histone modifications directly regulate the physical properties of chromatin and its corresponding transcriptional state. Long non-coding RNAs (lncRNAs) play essential roles in epigenetic modification processes, such as histone modification, DNA methylation, and chromosomal remodeling. In plants, lncRNAs repress histone-modifying activities and direct epigenetic silencing through interaction with specific chromatin domains.

Lifeasible provides analysis services for plant lncRNA in histone modifications to help our customers worldwide in plant science research. Our platform is equipped with cutting-edge facilities and professional experts to support research. Here, we provide various services according to customers’ demands.

Histone Acetylation

• Histone acetylation modification is one of the most essential epigenetic research components, closely related to gene activation. Increasing the level of histone acetylation facilitates the reduction of the affinity between histones and DNA, loosening the structure of chromatin nucleosomes. However, decreased acetylation levels exert the opposite effect.
• We provide analysis services for plant lncRNA in histone acetylation, involving the acetylation modification of lysine residues at the amino terminus of histone H3 (H3) and histone H4 (H4), which is particularly important for transcription. Histone acetylation facilitates the binding of transcription factors to DNA, promoting the transcription and expression of the corresponding genes.
• We also help our customers analyze the role of histone acetylases and histone deacetylases (HDAC) in modifying and regulating histone acetylation.

Fig. 1 The schematic representation of histone modifications.

Histone Methylation

• Histone methylation is the modification of certain amino acids in a histone protein by adding one, two, or three methyl groups. This modification alters the properties of the nucleosome and affects its interactions with other proteins.
• We provide analysis services for plant lncRNA in histone methylation. Methylation and demethylation of histones turn the genes in DNA "off" and "on,” respectively, either by loosening their tails, thereby allowing transcription factors and other proteins to access the DNA, or by encompassing their tails around the DNA, thereby restricting access to the DNA.
• We also help our customers analyze the critical roles in histone methylation. For instance, several plant lncRNAs recruit histone H3K4 methyltransferases to promote activation of gene expression, while others bind DNA methyltransferases, including DNMT1 and DNMT3b, to repress transcription by promoting DNA methylation.

Lifeasible provides cost-effective, high-quality, and hassle-free services to our customers worldwide. ​We provide our clients with direct access to our experts and prompt responses to their questions. If you are interested in our services or have questions, please feel free to contact us or make an online inquiry.

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Related Services

• Analysis of Plant lncRNA in DNA Methylation Modifications