Transcription is the process in which a gene's DNA sequence is copied (transcribed) to make an RNA molecule. The regulation of the preparatory phase before the transcriptional event occurs refers mainly to the regulation of the open or closed state of chromatin. The state of chromatin is determined by epistasis modifiers (essentially proteins), open state for those rich in activating histone modifications such as H3K4me3, H3K36me3, and histone acetylation; closed state for those rich in repressive histone modifications such as H3K9me3, H3K27me3, H4K20me3, and DNA methylation.

Lifeasible, as a leading global company, is committed to helping our customers achieve effective and successful research. We provide analysis services of plant lncRNA in pre-transcriptional regulation, mainly including DNA methylation or hydroxy-methylation and histone acetylation or methylation. In addition, we deliver reliable results and reports on time to our customers worldwide.

Analysis of Plant lncRNA in Histone Modifications

• Histone modifications are vital epigenetic regulators that control chromatin structure and gene transcription, impacting various important cellular phenotypes. It affects various DNA-induced processes such as gene transcription, DNA replication, recombination, and cell repair.

Fig. 1 Schematic representation of histone modification and DNA methylation.

• We help clients analyze the role of plant lncRNA in histone modifications. At least nine different types of histone modifications have been discovered. Among them, acetylation and methylation occur frequently under the regulation of lncRNA.
• We also help our customers analyze the critical roles in histone acetylation and methylation, such as histone acetylases and histone deacetylases (HDAC), histone H3K4 methyltransferases, and so on. Our detailed reports and output data files will be delivered to the client promptly.

Analysis of Plant lncRNA in DNA Methylation Modifications

• As an essential epigenetic modification, DNA methylation modifications can regulate gene expression by affecting chromatin structure, DNA architecture, stability, and protein interaction patterns.
• We offer analysis services for plant lncRNA in DNA methylation modifications. The mechanism of DNA methylation in plants is more complex than the process of DNA methylation in mammals. DNA methylation in plants is mainly accomplished through the process of transcriptional silencing of genes due to RNA interference.
• We provide analysis services of the role of plant lncRNA in the RNA-directed DNA methylation (RdDM) silencing pathway. RdDM corresponds to a plant-specific de novo DNA methylation mechanism that requires lncRNAs as a scaffold to define target genomic loci. Our services apply in various situations, including different developmental stages and abiotic stresses.

Lifeasible is always devoted to providing high-quality and satisfactory service to our customers. If you are interested in our services or have some questions, please feel free to contact us or make an online inquiry.

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Related Services

• Analysis of Plant lncRNA in Transcriptional Regulation
• Analysis of Plant lncRNA in Post-Transcriptional Regulation