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Epigenetic Analysis at the Chromatin Level
At the microscopic level, the study of epigenetics centers on chromatin, and more precisely, changes in chromatin structure that do not depend on changes in DNA sequence. Chromatin contains an individual's genetic information and is formed by DNA and histones. At different levels, chromatin structure is closely linked to the regulation of DNA expression. Epigenetic changes in DNA-histone complexes can determine gene activity by rapidly altering chromatin accessibility to transcription factors. Lifeasible provides you with chromatin remodeling service resolution services, and we also offer a variety of technical tools to help you with chromatin analysis.
We can provide you with complex structure analysis, chromosome 3D structure display of core subunit mutants, nucleosome density and distribution assay, and chromatin accessibility assay to help you study the mechanism of chromatin remodeling.
DNase-seq for plant epigenetics
We used DNase I to digest nuclear chromatin partially and sequenced the recovered DNA to analyze chromatin accessibility at the genome-wide level and to quantify the relative abundance of DNase-sensitive chromatin on a genome-wide scale.
MNase-seq for plant epigenetics
Given the central role of histones in regulating chromatin accessibility, we utilize MNase-seq technology to help you detect genome-wide nucleosome distribution and assess transcription factor binding, which can be used in a wide range of cell types.
ATAC-seq for plant epigenetics
We offer ATAC-seq technology services that combine high-throughput sequencing and biosignature analysis to study open regions of chromatin on a genome-wide scale systematically. We use ATAC-seq technology to simultaneously study open chromatin regions, transcription factor binding sites, and nucleosome occupancy.
NOMe-seq for plant epigenetics
We offer NOMe-seq, which allows customers to observe DNA methylation and nucleosome localization in the same DNA molecule, which will help them perform in-depth epigenetic studies. In addition to this, we are actively combining NOMe-seq and PBAT-seq technologies in a clever and systematic optimization and enhancement.
FAIRE-seq for plant epigenetics
FAIRE directly enriches the region of activated chromatin, which can be directly applied to any type of cell or tissue, with no requirement for the starting state of the cells. We use FAIRE-seq technology to identify chromatin accessibility and detect DNA sequences associated with regulatory activities on a genome-wide scale.
Genomic DNA is tightly packed in chromatin, and many life activities in the nucleus, such as gene expression, DNA replication, and repair, require chromatin depolymerization to facilitate the binding of various cytokines to DNA. Chromatin reassembly is performed after the completion of the corresponding functions to restore the chromatin structure. Lifeasible provides epigenetic services at the chromatin level, involving regulating chromatin-associated molecules such as DNA, non-coding RNAs, and histones. Please feel free to contact us for more information on our solutions.
The services provided by Lifeasible cover all aspects of plant research, please contact us to find out how we can help you achieve the next research breakthrough.
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