Epigenetics is involved in every stage of biological development and plays a critical regulatory role. Epigenetic research and breeding are new pathways and methods for breeding high-yielding and high-quality varieties. Using CRISPR/Cas9 technology, it is possible to alter chromatin remodeling factor binding sites to regulate transcription. Lifeasible provides you with epigenetic editing and breeding techniques with universal applicability for breeding high-yielding and high-biomass superior varieties to increase food production. In addition, the modified plants have well-developed root systems and are expected to be more adapted to drought-resistant, stress-resistant, and other environments.

• Our use of CRISPR/Cas9 for modifying species-specific, tissue-specific, and gene-region-specific epigenetic factors is suitable for exploring the causal relationship between epigenetic factors and gene expression, as well as the specific function of chromatin region structure.
• Our use of the CRISPR/Cas9 system allows us to target genomes with aberrant epigenetic modifications for error correction, as well as directly targeting mutation-producing factors associated with chromatin remodeling to restore their function.
• We used dCas9 together with specific modifiers to co-transfect living cells to achieve modification of target genes and chromatin modification and to understand more directly the specific functions at the cellular level and the specific roles of specific regions of modification at the gene level.
• We quantitatively replace methylate sites of target genes with simple codons, and transgenic manipulation can be achieved by designing synthetic genes for epigenetic manipulation of plant phenotypic plasticity traits.
• We use CRISPR/Cas9 technology to construct plant expression vectors to quantitatively replace the methylable sites of in situ in situ genes with syntenic codons and quantitatively regulate the methylation degree and gene expression level of exogenous or in situ in situ target genes to regulate the plasticity traits of target plants quantitatively.
• By quantitatively regulating the methylation level of key genes, we have bred plants with different resistance abilities, which provides a new option for breeding resistant crops through epigenetic technology.

Technical advantages

• Broad spectrum.
• Can be directly applied to various plants.
• Compared with traditional hybridization or molecular breeding, it has a short cycle and does not require knowledge of plant genome information and molecular biology research.

In addition, RNA mutations and modifications affect the life activities of plants and animals, and Lifeasible is trying to apply CRISPR/Cas9 technology to RNA mutations and modifications. So that you can explore acquired genetics, translational regulation of proteins, and viral detection of RNA to support the exploration of gene function and life science research, please feel free to contact our staff for more information.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

For research or industrial use.

Related Services

• Epigenetic Analysis at the Histone Level
• Epigenetic Analysis at the Chromatin Level
• Epigenetic Analysis at the RNA Level
• Analysis of Epigenetic Molecular Mechanisms
• Epigenetic of Plant Polyploidy
• Epigenetic Analysis at the Methylation Level