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Epigenetic Analysis at the Histone Level
Epigenetics has evolved from the superficial level of resolving single epigenetic controls in genomic regions to a more advanced level of histones and chromatin. Studying histone variants is an important part of eukaryotic epigenetics and plays an essential regulatory role in processes such as cell differentiation, development, and chromosome segregation. Histone chaperones are involved in transporting histones and chromatin assembly and de-assembly, among others. Histone arginine methylation can regulate specific proteins by interacting with various protein arginine methyltransferases (PRMTs), altering chromatin structure and regulating transcriptional processes. Lifeasible provides in-depth technical services for these critical biological processes, supporting your exploration of plant rooting, flowering, stress, and disease resistance.
Histone variants and histone modifications
We can help you study histone and variant modifications through chromatin immunoprecipitation sequencing (ChIP-seq) and cleavage under targets and tagmentation (CUT&Tag) related technologies.
Histone associated chaperone proteins
We enable you to characterize histone post-translational modification binding chaperones, helping you to study histone chaperone oligomerization and stability and reveal histone chaperone-histone interactions.
Our large-scale analysis of protein arginine methylation using methylation modification proteomics and mass spectrometry provides an ideal analytical strategy to study the extent of arginine-methylation of proteins in model systems and identify PRMT targets.
Histone proteins are essential in the environmental adaptation of plants as they regulate the expression level of corresponding genes through epigenetic modifications at different sites or to different degrees, thus affecting plant growth and development.
- Histone methylation. Methylation depends on its location and state and is associated with inhibition or activation.
- Histone acetylation. Acetylation may regulate gene transcription through its effects on histone charge and interacting proteins.
- Histone phosphorylation. The addition of a phosphate group to the four tails of a histone involves DNA damage.
Lifeasible provides technical services on histone variants, histone chaperones, and histone arginine methylation, which can provide you with new ideas for molecular biology, genetics, and evolutionary biology. In addition to this, we have newly introduced the services of histone methyltransferases (HMTs) activity or inhibition analysis assays (specifically for total type II PRMT, H3-K4, H3-K9, and H3-K27) and histone demethylase activity or inhibition assays (mainly for KDM1/LSD1, PAD4/PADI4, and JmjC). Please feel free to contact our staff for technical solutions.
The services provided by Lifeasible cover all aspects of plant research, please contact us to find out how we can help you achieve the next research breakthrough.
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For research use only, not intended for any clinical use.
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