Messenger RNA (mRNA) stability in almost all living organisms influences gene expression and translation. Maintaining an accurate balance of production and decay is crucial for the correct function of various biological processes and for maintaining appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) are RNA molecules without protein-coding potential with lengths exceeding 200 nucleotides. They are emerging as prominent regulators of mRNA stability and decay.

Lifeasible provides analysis service of plant lncRNA in RNA stability regulation to help our customers worldwide in plant science research. Our platform is equipped with cutting-edge facilities and professional experts to support research. Here, we provide various services according to customers' demands.

Inducing miRNA Blockage

Fig. 1 lncRNA/miRNA/mRNA axis regulation.

• MicroRNAs (miRNA) are small, highly conserved, non-coding RNA molecules involved in the regulation of gene expression. They can silence cytoplasmic mRNAs by triggering an endonuclease cleavage, promoting translation repression, or accelerating mRNA de-adenylation and de-capping.
• We provide analysis services of plant lncRNA that affect mRNA stability via miRNA blockage. lncRNAs can prevent the interaction of miRNAs with target mRNAs to protect them from miRNA-driven degradation. On the one hand, the plant lncRNA can sequester miRNAs, avoiding their binding to target mRNAs, and on the other hand, they can directly interact with target mRNA transcripts to block miRNA binding sites in mRNA molecules.

Interacting with RNA-Binding Proteins

• RNA-binding proteins (RBPs) bind to the double or single-stranded RNA in cells and form ribonucleoprotein complexes. Various RBPs regulate mRNA stability and/or translation efficiency by binding to different sequence protomers in the mRNA 3'-UTR.
• We provide analysis services of plant lncRNA that interact with RBPs. lncRNAs can also be cytoplasmic and bind RBPs to affect other mRNA metabolism processes, such as mRNA stability and turnover. In some cases, lncRNAs bind to mRNA transcripts and help to recruit RBPs affecting mRNA levels.

LncRNAs Involved in Epi-Transcriptomic Changes

We help clients analyze the role of lncRNA in epi-transcriptomic changes, such as lncRNAs influencing N6-methyladenosine (m⁶A)-mediated mRNA stability. It has been stated that regulating mRNA stability through RNA modification is a crucial step for the tight regulation of gene expression. Among them, m⁶A methylation is the most prevalent RNA modification in mRNAs and noncoding RNAs.

Lifeasible provides cost-effective, high-quality, and hassle-free services to our customers worldwide. ​We provide our clients with direct access to our experts and prompt responses to their questions. If you are interested in our services or have questions, please feel free to contact us or make an online inquiry.

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Related Services

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• Analysis of Plant lncRNA-Mediated RNA Degradation