Plant Proteomic of Post-Translational Modifications

Post-translational modifications (PTMs) refer to the covalent processing of post-translational proteins. By adding a modification group to one or more amino acid residues, it can change the physical and chemical properties of the protein, which in turn affects the spatial conformation and activity state, subcellular localization, folding and its stability as well as protein-protein interactions, affecting almost all aspects of normal cell biology.

Figure 1. General overview of the steps involved in the creation of a targeted proteomics experiment for monitoring phosphorylated peptides. (Borjana A., et al., 2018)

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Since post-translational modified proteins are low in the sample and have a wide dynamic range, they must be enriched before identification. Besides, the stability of the modifications and the detection efficiency of mass spectrometry are key factors in the analysis of PTMs. Lifeasible has built an advanced analytical platform to characterize PTMs within various plant proteins, and the protein modifications that have been studied at scale are mainly methylation, phosphorylation, acetylation, glycosylation, ubiquitination, etc.

Reference

Borjana A., et al. "Monitoring of Plant Protein Post-Translational Modifications Using Targeted Proteomics." Frontiers in Plant Science, 2018, 9:1168.

The services provided by Lifeasible cover all aspects of plant research, please contact us to find out how we can help you achieve the next research breakthrough.

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