Initially, lncRNAs were considered as "noise" of genomic transcription, a by-product of RNA polymerase II transcription, and had no biological function. The development and application of whole genome sequencing technology have significantly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). Currently, studies in the literature have shown that lncRNAs are involved in various critical regulatory processes such as X chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference, and intranuclear transport. These regulatory roles of lncRNAs are also beginning to attract widespread attention.

Lifeasible, as a leading global company, is committed to helping our customers achieve effective and successful research. We provide analysis services for plant lncRNA regulation mechanisms, from pre-transcriptional, transcriptional to post-transcriptional. In addition, we deliver reliable results and reports on time to our customers worldwide.

Analysis of Plant lncRNA in Pre-Transcriptional Regulation

• The regulation of the preparatory phase before the transcriptional event by lncRNAs refers mainly to regulating the open or closed state of chromatin. One part of the lncRNA region binds to DNA, and then other parts fold into higher structures that bind to epistasis factors, thus affecting transcription.
• We help clients analyze the role of plant lncRNA in pre-transcription regulation, mainly including DNA methylation or hydroxy-methylation and histone acetylation or methylation.

Analysis of Plant lncRNA in Transcriptional Regulation

• Transcriptional regulation refers to regulating the transcriptional process, specifically the transcription of class II promoters involved in RNA pol II. The transcription process is divided into 3 processes, initiation, elongation, and termination.

Fig. 1 The three stages of transcription.

• We provide analysis services of plant lncRNA in transcriptional regulation, including but not limited to enhancer activity of lncRNAs, lncRNA regulation of insulator function, transcriptional interference function of lncRNAs, and lncRNA control of transcription factors, etc.

Analysis of Plant lncRNA in Post-Transcriptional Regulation

• Besides the well-established function of lncRNAs in transcriptional and epigenetic gene regulation, lncRNAs also possess the potential to promote and inhibit the post-transcriptional processes of mRNA splicing, degradation, and translation.
• We help our clients analyze the role of plant lncRNA in post-transcriptional regulation, mainly including lncRNA involved in variable shear regulation, lncRNA mediated RNA degradation, lncRNA involved in RNA stability regulation, and others.

Lifeasible is always devoted to providing high-quality and satisfactory service to our customers. If you are interested in our services or have some questions, please feel free to contact us or make an online inquiry.

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