Salinity and alkalinity stress are among the most serious challenges facing global agriculture. In plants, this stress primarily manifests as osmotic stress, ion toxicity, and the secondary stresses that result from them. Breeding salt-alkali-tolerant plants to adapt to saline-alkali soils can fundamentally resolve the issue of utilizing such lands. Endogenous hormones play a central regulatory role in normal plant growth and development as well as in stress responses. By precisely manipulating the synthesis, signal transduction, or metabolic pathways of endogenous hormones, we can systematically enhance plants' comprehensive adaptive capacity to salt-alkali stress.

Leveraging our deep expertise in plant physiology and cutting-edge biotechnological methods, Lifeasible offers hormone-regulated plant modification services to enhance salt and alkali tolerance. We are committed to providing customized solutions to address salt-alkali stress in agricultural breeding, forestry improvement, and ecological restoration by precisely regulating endogenous hormone metabolism and signal transduction pathways.

Fig.1 Plant saline-alkali tolerance. (Lifeasible)

Our Service for Phytohormone-Directed Engineering for Plant Saline-Alkali Tolerance

Plant hormone-protein interactionomics and target identification

When plants are subjected to salinity and alkalinity stress, hormone signaling relies on complex protein interaction networks. Our plant hormone-protein interactionomics and target identification services help facilitate the precise prevention and control of salinity and alkalinity stress in plants. This includes high-throughput interactomics screening using in situ affinity purification-mass spectrometry (AP-MS) and high-throughput yeast two-hybrid systems (Y2H-Seq) to dynamically capture the binding states of core hormone receptors—such as abscisic acid (ABA) and jasmonic acid (JA)—with downstream response proteins and transcription factors during saline-alkali stress.

Concurrently, through structural analysis and precise target localization—leveraging cryo-electron microscopy and high-precision molecular dynamics simulations—we determine the three-dimensional crystal structures of "ligand-receptor" complexes to precisely identify key endogenous protein interaction sites, thereby providing a scientific basis for subsequent precision modifications.

Multi-target gene editing and directed breeding for plant salt and alkali tolerance

Traditional breeding for salt and alkali tolerance faces the challenge posed by complex quantitative traits arising from polygenic co-regulation of plant tolerance. Manipulation of a single gene often fails to yield significant phenotypic improvements. By systematically analyzing the hormonal signaling networks of target crops, we identify and regulate key "upstream switches"—such as kinases, transcription factors, or hormone-synthesis genes—to achieve cascading, synergistic expression of multiple downstream effector genes, thereby reshaping the plant's diverse stress-response mechanisms at the systemic level. Leveraging advanced gene-editing technologies, we make targeted improvements in plant salt and alkali tolerance to overcome the phenotypic bottlenecks of single-gene modifications and achieve systematic enhancements in complex stress-resistance traits.

Development of smart plant hormone nano-delivery carriers

For recipient organisms unsuitable for genetic modification—such as ancient and rare trees and mature landscape plants—highly permeable, sustained-release exogenous regulatory methods can be employed to confer resistance to salt and alkali stress.

• High-efficiency barrier penetration. The surface of nanoparticles is modified with a special hydrophilic or lipophilic balance, enabling efficient penetration of the plant leaf cuticle barrier or root endodermis, significantly enhancing drug bioavailability.
• Stress-responsive, precise release. The vehicle encapsulates highly stable endogenous hormone analogs and is constructed using environment-sensitive materials. When the pH of the soil or plant sap rises due to salinization or alkalization, the nanostructure undergoes physical swelling or chemical bond cleavage, thereby enabling intelligent response and precise, slow-release of the hormone molecules.

Fig.2 Our service process. (Lifeasible)

Highlights of Our Services

• Scientifically sound and reliable. Our technological approach is grounded in the latest scientific research, with each target for modification supported by well-defined molecular mechanisms and functional validation.
• Multi-target synergistic modification. We adhere to a systematic strategy of "synergistic modification of multiple hormonal pathways," simultaneously targeting key nodes such as ABA signaling, the JA pathway, and auxin regulation to achieve synergistic effects.
• Robust technical platforms. We possess an in-house gene-editing vector library, a high-throughput genetic transformation platform, and intelligent greenhouse facilities, enabling us to manage modification projects across multiple species concurrently.

Lifeasible specializes in the research and application of phytohormones. We are committed to leveraging the latest findings in Phytohormone biology to provide professional and reliable technical solutions for the development of agriculture on saline-alkali lands worldwide. If you are interested, please feel free to contact us.

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